Re: FMC7 AND INTERMEDIATE CELL LYMPHOMA

hugh johnson (hugh@cei.net)
Thu, 12 Jun 1997 07:34:28 -0500

Maryalice Stetler-Stevenson wrote:
>
> I can't cite statistics but from our clinical experience, FMC7 is extremely
> sensitive for mantle cell but not specific (many other lymphomas are FMC7
> positive). I have never had a real mantle cell lymphoma that was FMC7
> negative (most consistent with Mantle cell doesn't count as these are
> usually something in between real mantle cell and something else). It is
> useful in differentiating CD5+ neoplasms with the appropriate morphology. A
> CD5+ neplasm that is FMC7+ and CD23- and has small lymphoid cells with
> compact chromatin as well as some what cleaved nuclei is mantle cell. But
> then of course, nothing stands alone in diagnosis of neoplasia. If you have
> a specific example, what are the other antigens studied?
>
> Maryalice
>
> >HEY,
> >DOES ANYONE KNOW THE SENSITIVITY AND SPECIFICITY OF FMC7 IN THE FACE OF A
> >PICTURE THAT APPEARS TO REPRESENT INTERMEDIATE CELL (MANTLE CELL OR ZONE)
> >LYMPHOMA IN HUMANS (FOR YOU PURISTS). THANKS SO MUCH, MELISSA L. BEAL, M.D.
>
> Maryalice Stetler-Stevenson
> Director Flow Cytometry Unit
> Laboratory of Pathology, NCI, NIH
MaryAlice,

Should you run FMC7 if you have cd19+, cd23-/cd5+ lymphoma? Our
pathologist, when I approached him with this, believes it isn't
necessary. You already, if the histology agrees, have a mantle zone
presentation without FMC7 positivity.

For our lymphoma panels we run cd3/cd19, cd5, cd10, cd23, kappa, lambda
for B, appropriate T markers if not B.

thanks,

hugh johnson
flow lab guy
st vincent infirmary medical center
little rock, ar