I have had some experience with this entity and we are writing up the Mayo
cases seen so far. Unfortunately, its an aggressive disease. There are no
known protocols - its really too rare for a protocol. I'd recommend: 1. An
adriamycin containing regimen such as CHOP, CDE infusional (actually ECOG does
have this open as a protocol and the patient could probably enter it --its for
aggressive NHL not specifically gamma-delta), ProMACECytaBOM
2. If responsive, I'd check the blood and marrow and transplant if clean. 3.
If not a transplant candidate and does not get a CR with regimen in #1 then
I'd try a platinum regimen OR 2-deoxycoformycin- Pentostatin (good for T-cell
processes and commercially available and usually outpatient and
well-tolerated.
Sincerely,
Tom Witzig (witzig.thomas@mayo.edu)