Maryalice
>Hi everyone,
>We recently processed a hepatosplenic lymphoma in an 18 y/o BM which was ve=
ry
>aggressive and which had the following phenotype:
>CD2+, CD3+, CD5-, CD7+, gamma/delta-TCR+, alpha/beta-TcR+, CD4-, CD8=D2, CD=
56+,
>and CD11c+. It showed J-Beta rearrangement bands, and this resembles the ra=
re,
>but previously reported cases of aggressive gamma-delta T cell lymphomas.
>Checking several times, we confirmed the coexistence of the two forms of T
>cell
>receptor (a/b, g/d) on the cell surface. I have never seen any T cell
>tumor that
>coexpressed two TCR forms and I would appreciate any comments or advice fro=
m
>those of you who may have had previous experience with a similar tumor.
>
>Thanks,
>
>Phil Ruiz
>U. of Miami
Maryalice Stetler-Stevenson
Director Flow Cytometry Unit
Laboratory of Pathology, NCI, NIH