Re: CD10 expression in follicular lymphoma

Arber, Daniel (darber@smtplink.Coh.ORG)
Mon, 06 Jan 97 08:37:20 pst

Brent,

You describe a non-specific monotypic B cell immunophenotype which
could be present in a number of different lymphoproliferative
disorders. While some follicular lymphomas are CD10 negative,
marginal zone lymphomas may also have this phenotype. The actual
pattern of the lymphoid infiltrate would be more helpful in suggesting
follicular lymphoma.

Dan Arber
City of Hope
Duarte, CA

______________________________ Reply Separator _________________________________
Subject: CD10 expression in follicular lymphoma
Author: Brent Dorsett <brentd@nyct.net> at INTERNET
Date: 1/3/97 7:58 PM

Happy year year to one and all.

I have a bone marrow biopsy on a 63 yr old male with severe peripheral
pancytopenea. Biopsy is atypical lymphoid infiltrate consistent with NHL
small cleaved cell. Light scatter shows a single population of small
lymphocytes. The phenotype is CD5-, CD19+, CD22+, CD10-, CD20+, CD25-, CD23-,
CD103-, CD11c-, kappa bright positive, lambda negative. Seems to fit best
with follicular lymphoma except for the CD10 negativity. I wonder what others
of you may think about this phenotype?

Thanks,

Brent Dorsett
Director, Special Pathology Laboratories, Lenox Hill Hospital, NYC