BMS 602

Biophysical and Clinical Aspects of Tissue Repair and Regeneration


1 credit hour
Fall semester

instructor
	S. L. Voytik-Harbin

prerequisites
	Consent of Instructor

description
Tissue regeneration and repair involves a complex programmed sequence of
 cellular and molecular processes, including inflammation, cell migration,
 angiogenesis, provisional matrix synthesis and assembly, and tissue-specific
 mrophogensis.  This course will provide an integrative look at the
 biological, biophysical, and clinical principles of tissue regeneration 
and repair.  Participants will learn the fundamental differences between
 "regeneration" and "repair" as well as fetal and adult wound healing.
  The dynamic changes in the extracellular matrix and cell-matrix interactions
 that occur after tissue injury will be presented.  Emphasis will be
 placed on biophysical properties of the wound microenvironment and 
their affects on restoration of tissue/organ structure and function. 
 Current perspectives and strategies for augmentation of would healing
 and development of bioartificial tissue and organs will also be discussed.
  At the end of the course all participants should have a full integrative 
understanding of both engineering and life science aspects of tissue
 regeneration and repair.

text
Wound Healing: Biochemical and Clinical Aspects.  Cohen I.K., Diegelmann R. R., and Lindblad W.J. (eds.) W. B. Saunders Company, Philadelphia, PA 1992.  Selected relevant journal articles.

outline

1.	Course overview; Regeneration vs. Repair; Fetal vs. Adult Wound Healing
2.	Phases of wound repair:  Haemostasis and Inflammation; Angiogenesis
3.	Phases of wound repair:  Granulation tissue formation; Tissue remodeling
4.	Cellular process and control of tissue repair
5.	Extracellular matrix and molecular mediators of tissue repair
6.	Growth Factors and Regulation of Tissue Repair
7.	Biophysical aspects of wound repair
8.	Midterm Exam
9.	Skin repair
10.	Bone and cartilage repair
11.	Tendon and ligament repair
12.	Nerve repair
13.	Organ repair
14.	Current perspectives on wound management:  Wound dressings and biomaterials
15.	Current perspectives on wound management: Bioartificial organs and biomedical devices
16. 	Final Exam

For further information regarding the Biomedical Engineering Program at Purdue University contact the Biomedical Engineering Graduate Office at (317) 494-5730 bmeprogram@ecn.purdue.edu