CD38
ACTIVATED T CELLS
The CD38 antigen is a type II integral membrane glycoprotein with the NH2-terminus inside the cytoplasm.Its molecular weight is about 45 kDa. Its tissue distribution appears to be dependent on the differentiation and activation of the cell. It is expressed on activated T and B cells, monocytes, NK cells, plasma cells and medullary thymocytes. It is also present on terminally differentiated B cells and early B cells. However, most mature resting peripheral lymphocytes of both B and T lineages do not express CD38 antigen. The LS198-4-3 antibody was characterized during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.
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