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The blast cells which appear during acute transformation of CML have
been charaterized as resembling lymphoblasts (ie. CD10+/CD19+).
This is true in lymphoid blast crisis, but in myeloid blast crisis the blast
cells of course have a myeloid phenotype. Myeloid blast crisis occurs in about
75% of cases and lymphoid in about 25% of cases. (I'm sure this was just an
oversight in your post, but thought I would make this clear for those with less
experience with hematologic disorders).
Karen Mann
Clinical Flow Cytometry
Duke University Medical Center
Durham, NC
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CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
Web
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CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
Web