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Two questions to all DNA'ers in Flowland.
1. Do you think this peak represent a de-novo neoplastic population
"transformed" from (? virally) activated T cells ?
We have read of EB virus causing malignancies of this phenotype, but nothing on
heterogeneity of DNA indexes in such neoplasms.
2. Has anyone seen a non-malignant S phase showing such a peak, which would
suggest an arrest of "normal" proliferating cells, all at exactly the same
stage of DNA synthesis.
No treatment was being administered at the time which could account for this
arrest so I guess it would have to be put down to apoptosis at a very specific
point in the cell cycle.
I stress that this PI peak is very tight, with the CV's one would normally
associate with a cohort population.
Unfortunately we do not yet have any method available here of proving clonality
in T cells.
Clinical signs are ambiguous
Any comments and hypotheses welcome - we're stumped and also divided in opinion
!
Wal Sharp
SQU
Oman
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CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
Web
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CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
Web