LINCOSAMIDES
Outline

Copyright, Purdue Research Foundation, 1996


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Notice

Members

Structure and Characteristics

Lincosamide Structure

Chemistry

Physical Incompatibilities of clindamycin

Pharmacokinetics

Administration

Distribution

Elimination

Adverse Effects
(Both drugs)

Overview

Antibiotic-Associated Pseudomembranous Colitis (AAPC)

Indications
(Both drugs)

References

Study Questions

  1. What is the antibacterial spectrum of the lincosamides? Note that in addition to other organisms, these drugs are active against anaerobic bacteria, e.g., Bacteroides spp. This is expeicaly important for Bacteroides fragilis which tends to be resistant to penicillins.
  2. Note the high incidence of diarrhea under some circumstances with the lincosamides (lincomycin, esp), particularly in humans and horses. What is the usual cause of this diarrhea when it is severe and ulcerative? Why is lincomycin much worse than clindamycin in inhibiting the normal intestinal flora?
  3. What antibiotic is specifically recommended for treating the Clostridium difficile infections mentioned in the previous question?

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Gordon L. Coppoc, DVM, PhD
Professor of Veterinary Pharmacology
Head, Department of Basic Medical Sciences
School of Veterinary Medicine
Purdue University
West Lafayette, IN 47907-1246
Tel: 317-494-8633Fax: 317-494-0781
Email: coppoc@vet.purdue.edu

Last modified 11:13 AM on 4/10/96 GLC