AMINOGLYCOSIDE ANTIBACTERIALS

Copyright, Purdue Research Foundation, 1996


| Drug Groups | | Address | | Full |

Overview

Members

Structure & Chemical Characteristics

Mechanism of action

Resistance

Pharmacokinetics

Membrane transfer

Other pharmacokinetics

Distribution

Elimination

Schemes for dosage adjustment assistance

Target concentrations


       Drug           Therapeutic        Maximum Peak       Maximum Trough   
                     Concentration       Concentration      Concentration    
                        (mcg/mL)           (mcg/mL)            (mcg/mL)      

Amikacin                 15-25                35                  5          

Gentamicin                4-10                10                  2          

Kanamycin                15-30               30-35                5          

Netilmicin                6-12                16                  2          

Streptomycin               --               20-25*                --         

Tobramycin                4-10                10                  2          

* In patients with renal damage. Peak concentrations greater than 50 mcg  
per mL are associated with increased risk of toxicity. [USPDI95,71]       


Adverse effects

Nephrotoxicity

Ototoxicity: cochlear and vestibular apparatus

Neuromuscular paralysis

Clincal use